相关实验视频

Updated: Jan 13, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

洗净的微生物移植可以通过肠皮肤微生物组再平衡来缓解亚托皮炎

Wanying Deng¹, Dongmian Chen², Yaofei Wei²

¹Department of Dermatology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

BMC microbiology

|January 11, 2026

概括

洗微生物种移植 (WMT) 通过改善皮肤症状和重塑肠道和皮肤微生物平衡,有效治疗亚托皮炎 (AD). 这种以微生物群为中心的疗法对免疫介导的皮肤疾病有前途.

科学领域:

微生物组研究的研究.
皮肤病学皮肤病学
免疫学免疫学免疫学

背景情况:

亚托匹性皮肤炎 (AD) 的发病过程涉及肠道和皮肤的微生物失调.
洗微生物种移植 (WMT) 是一种先进的便微生物种移植 (FMT),有可能用于AD治疗.
关于WMT在阿尔茨海默病中的疗效和微生物影响的临床数据有限.

研究的目的:

评估WMT在中度至重度亚托皮性皮肤炎患者的安全性和有效性.
调查WMT对肠道和皮肤微生物群组成和多样性的影响.
评估WMT对临床疾病活性和AD患者报告结果的影响.

主要方法:

23名中度至重度AD患者至少接受了两次WMT疗程.
通过SCORAD,EASI,的NRS和DLQI评估临床结果.
治疗前和后分析的周围血液计数,细胞因子,淋巴细胞子集和肠/皮肤微生物群.

主要成果:

WMT被很好地容忍,副作用最小.
在SCORAD,EASI,DLQI和NRS得分中观察到显著的改善.
肠道微生物群表现出改善的健康指数和增加的有益细菌;皮肤微生物群从葡萄球菌主导转向潜在的保护性基因.

结论:

WMT是一种安全有效的皮炎干预措施,可以改善临床症状.
WMT重塑肠道和皮肤微生物群,支持肠-皮肤轴作为治疗点.
WMT代表了一种有希望的以微生物群为中心的方法来治疗免疫媒介皮肤疾病.

关键词:

亚托邦性皮肤炎 (Atopic Dermatitis) 是一种疾病.肠-皮肤轴肠-皮肤轴微生物群中的微生物群洗净的微生物群移植

更多相关视频

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

相关概念视频

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...