母体转移前血清脂质过氧化率升高与植入失败和早期妊娠损失有关
Zhangwei Jia1,2,3,4,5,6,7,8,9, Junxiang Ren1,2,3,4,5,6,7,8, Tianxiang Ni1,3,4,5,6,7,8
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
BMC medicine
|January 11, 2026
概括
脂质过氧化率升高,以马隆迪甲 (MDA) 和铁水平为指标,与辅助生殖技术 (ART) 中的植入失败有关. 这种过氧化可能会损害子宫内膜的受体性和决定性,影响怀孕的结果.
科学领域:
- 生殖生物学 生殖生物学
- 生物化学 生物化学
- 辅助生殖技术 辅助生殖技术
背景情况:
- 胚胎植入失败和早期妊娠损失是辅助生殖技术 (ART) 的重大挑战.
- 脂质过氧化在生殖生理学中的作用已知,但其对植入和胚胎移植后结果的具体影响需要进一步了解.
研究的目的:
- 调查母体脂质过氧化标志物与辅助生殖技术 (ART) 的结果之间的关联.
- 探索脂质过氧化对子宫内膜接受性和决定性的影响.
主要方法:
- 一项翻译性研究将临床数据 (分别来自2040名和487名患者的血清和子宫液样本) 与小鼠模型相结合.
- 临床分析包括倾向性得分匹配,逻辑回归,受限制的立方线和子组分析.
- 一个小鼠模型在植入窗口期间给出了埃拉斯,以评估子宫内膜受体性和断层化.
主要成果:
- 血清甲酸 (MDA) 和非血红铁水平的升高与复发性植入失败 (RIF) 独立相关.
- 在没有RIF的患者中,MDA升高,非血红素铁,12-HETE和15-HETE与植入失败和早期妊娠损失有关.
- 鼠标研究证实,在植入窗口期间增加的脂质过氧化会损害子宫内膜受容性和决定性.
结论:
- 升高的母体脂质过氧化与RIF独立相关,并且与非RIF患者的植入失败和早期妊娠损失有关.
- 子宫内膜对脂质过氧化特别敏感,这可能会对受体性和决定性产生负面影响.
- 这些发现表明,研究还氧化调节策略可以改善ART的结果.
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