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Updated: Jan 13, 2026

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用Bacillus subtilis的代谢工程来增强通过酶-底盘协同优化策略的自由血红素生物合成

Shuoqi Diao1, Haoqiang Zhou1, Yang Li1

  • 1School of Life Science and Technology, Wuhan Polytechnic University, Wuhan, 430023, People's Republic of China.

Biotechnology letters
|January 11, 2026
PubMed
概括

研究人员使用工程酶和微生物宿主增强了自由血红素生产. 在细菌中优化的谷氨基-tRNA减少酶 (GluTR) 在工业应用中实现了海姆产量的显著改善.

关键词:
这种细菌是 Bacillus subtilis.5 - 氨基氨基氨基氨基酸.谷氨基-tRNA减少酶的作用这里是Heme Heme.

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Biosynthesis in bacteria is a fundamental anabolic process that generates essential macromolecules, including proteins, nucleic acids, lipids, and polysaccharides. These macromolecules are critical for cellular growth, replication, and function. The process is tightly regulated and energetically linked to catabolic pathways to ensure optimal resource utilization.Biosynthetic pathways begin with precursor metabolites such as pyruvate, acetyl-CoA, and glucose-6-phosphate derived from glycolysis,...
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