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儿科手术中的抗生素预防:当更多不是更好或更安全的时候
Philip K W Hong1, Rachel Raymond2, Cristina Crippen1
1Department of Surgery, University of Florida, 1600 SW Archer Rd, Gainesville, FL, USA.
Pediatric surgery international
|January 11, 2026
概括
在儿科手术中适当使用抗生素至关重要. 手术抗生素预防 (SAP) 的治疗不足会增加感染风险,而过度治疗可能会减少尿路感染,但需要小心选择抗生素.
科学领域:
- 儿科手术 儿科手术
- 传染病流行病学 传染病流行病学
- 抗微生物药物管理委员会
背景情况:
- 抗生素耐药性构成了重大的公共卫生挑战.
- 手术抗生素预防 (SAP) 对于预防手术部位感染 (SSI) 是必不可少的.
- 不适当的SAP使用可能会导致不良结果,并有助于抵抗.
研究的目的:
- 评估手术抗生素预防 (SAP) 对儿科手术术后感染的适宜性的影响.
- 为了比较beta-lactam与非β-lactam抗生素在儿科手术患者的使用结果.
主要方法:
- 对ACS NSQIP儿科数据 (2021-2023) 的回顾性队列分析.
- 排除标准:先前存在的感染,恶性瘤,免疫缺陷,新出现的手术.
- 后勤回归用于评估SAP适当性与术后感染之间的关联.
主要成果:
- 治疗不足的SAP与SSI,败血症,C. difficile大肠炎和尿路感染 (UTI) 的几率增加有关.
- 过度治疗SAP与尿路感染的几率降低有关.
- 与β-乳酸抗生素相比,非β-乳酸抗生素显示肺炎的几率更高.
结论:
- 适当的手术抗生素预防 (SAP) 对于尽量减少儿科手术中术后感染至关重要.
- 抗生素选择是儿童手术患者管理结果的关键因素.
- 遵守SAP的指导方针对于患者安全和打击抗生素耐药性至关重要.
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