危险饮酒对中枢血动力学和中年成人大动脉硬性的影响
Keng-Yu Chang1, Zhaoli Liu2, Hitesh Nirmal1
1Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA.
Physiological reports
|January 11, 2026
概括
危险饮酒会提高中年成人中枢血压,但不会影响大动脉硬. 这些发现表明其他机制参与其中,而不是大动脉硬化或波反射.
科学领域:
- 心血管生理学心血管生理学
- 公共卫生 公共卫生
- 酒精研究研究 酒精研究
背景情况:
- 风险饮酒在中年成年人中普遍存在.
- 饮酒会影响心血管健康.
- 中心血动力学和大动脉硬是心血管风险的关键指标.
研究的目的:
- 调查风险饮酒与中央血液动力学之间的关联.
- 为了确定危险饮酒对中年成人大动脉硬性的影响.
- 探索将酒精消费与心血管变化联系在一起的潜在机制.
主要方法:
- 横截面研究设计. 截面研究设计.
- 包括79名年龄在50-64岁的中年成人 (男性和绝经后女性).
- 使用美国酒精使用障碍识别测试 (USAUDIT-C) 评估酒精消费.
- 测量中心血压,大动脉波反射指数,以及带至股骨脉冲波速率 (cfPWV).
主要成果:
- 与低风险饮酒者相比,风险饮酒者,特别是那些没有接受高血压治疗的人,表现出较高的中央缩和腹缩血压.
- 在风险饮酒者和低风险饮酒者之间,无论性别或药物使用,都没有观察到大动脉波反射指数或cfPWV的显著差异.
- 风险饮酒者中中心血压升高并没有独立地与大动脉硬化或波反射有关.
结论:
- 危险饮酒与中年成人中心血压升高有关.
- 观察到的中央血压的增加很可能是由除了大动脉硬化或波反射之外的其他因素引起的.
- 需要进一步的研究,以阐明与危险饮酒与中央血液动力学变化有关的确切机制.
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