在老鼠中对多草药混合物的急性和亚急性毒性评估
Prajakta H Murudkar1, Akshay M Baheti1, Anil T Pawar1
1Department of Pharmaceutical Sciences, School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, India.
Drug and chemical toxicology
|January 11, 2026
概括
这项研究发现,一种含有八种传统草药的多草药混合物,对Wistar老鼠是安全的. 急性口服毒性测试在2000mg/kg时没有显示任何不良影响,次急性测试在28天的重复剂量后没有显示任何毒性.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 草药研究 草药研究
- 临床前安全评估
背景情况:
- 多草药混合物被广泛用于各种健康状况,通常假定具有固有的安全性.
- 对这种复杂的草药配方的安全性概况进行科学评估至关重要.
研究的目的:
- 在Wistar大鼠中评估特定多草药混合物的急性和亚急性口服毒性.
- 为了确定多草药混合物口服的安全极限.
主要方法:
- 使用经合组织指南423 (一次剂量高达2000mg/kg) 评估了急性口服毒性.
- 亚急性毒性在28天内通过重复口服剂量 (250,500,1000毫克/公斤) 评估,遵循经合组织指南407.
- 参数包括死亡率,临床症状,体重,食物/水摄入量,血液学,生物化学,器官重量和组织病理学.
主要成果:
- 中位数致命剂量 (LD50) 确定大于2000 mg/kg,在急性研究中没有观察到死亡率或毒性迹象.
- 在为期28天的亚急性毒性研究中,没有注意到体重,食物/水消耗,血液学或生物化学参数的显著变化.
- 器官体重和组织病理学检查显示,在任何测试组中都没有与治疗相关的不良影响.
结论:
- 多草药混合物在一次口服剂量高达2000mg/kg时是安全的.
- 在28天内重复口服多草药混合物高达1000毫克/公斤的剂量,在Wistar大鼠中没有引起毒性.
- 这些发现支持这种多草药配方在测试剂量范围内的安全性.
相关概念视频
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01:23Toxicity Testing in Animals
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