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从产前期到青春期暴露于烟草烟雾驱动IBD病变:跨生命周期阶段的动态DNA甲基化特征
Han Zhang1,2, Jianhui Zhao1, Jie Chen3,4
1Department of Big Data in Health Science, The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
怀孕期间母亲吸烟 (MSDP) 可能会增加后代的数量.
科学领域:
- 环境流行病学环境流行病学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 胃肠病学 胃肠病学
背景情况:
- 早期吸烟暴露与炎症性肠病 (IBD) 之间的联系需要进一步调查.
- 在调解吸烟和IBD之间的关联中,DNA甲基化的作用尚不清楚.
研究的目的:
- 调查怀孕期间母亲吸烟 (MSDP) 与后代患IBD,克罗恩病 (CD) 和性结肠炎 (UC) 的风险之间的联系.
- 探索DNA甲基化在这些关联中的作用.
- 研究青少年吸烟对CD和IBD风险的影响.
主要方法:
- 综合研究设计分析吸烟暴露与IBD之间的关联.
- 检查特定基因 (例如ADCY7,AKAP8L,TIGD7,TNF/LTA,PRRT1,AHRR,MYO1G) 中的DNA甲基化模式.
- 分析不同生命阶段的甲基化变化.
主要成果:
- MSDP与后代患IBD,CD和UC的风险增加有关.
- 青少年吸烟与更高的CD和IBD风险有关.
- 在特定基因中MSDP诱导的DNA甲基化变化与增加的CD和UC风险相关.
- 吸烟相关的DNA甲基化变化可以持续一生.
结论:
- MSDP可能是后代IBD的独立风险因素.
- 在青春期积极吸烟会增加患CD和IBD的风险.
- 通过持久的表观遗传修饰,MSDP可能会导致IBD易感性.
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