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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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在衰老的牙伤口中,TGF-β-依赖的α11整体蛋白表达减少.

Susana Ríos1, Yongqiang Wang2, Valeria Muñoz1

  • 1School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de, Santiago, Chile.

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衰老的衰老 衰老的衰老原蛋白是一种原蛋白.结合组织结合组织.纤维细胞的细胞.整合物是一种整合物.伤口愈合 伤口愈合

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科学领域:

  • 细胞生物学 细胞生物学
  • 连接组织生物学 连接组织生物学
  • 伤口治愈研究研究 伤口治愈研究

背景情况:

  • 转化生长因子-β (TGF-β) 调节α11整合素,这是一个关键的原受体,对伤口修复至关重要.
  • 衰老的哺乳动物中受损的伤口愈合表明TGF-β信号通路的与年龄相关的变化.

研究的目的:

  • 调查衰老如何影响TGF-β介导α11整体蛋白在牙修复过程中的表达.
  • 阐明TGF-β信号减少在老年人受损结缔组织愈合中的作用.

主要方法:

  • 来自年轻和老年捐赠者的原发性人类牙纤维细胞被通过RT-qPCR和西欧涂抹分析,以检测整体蛋白和TGF-β的表达.
  • 使用基因记者试验评估TGF-β活性,ELISA量化TGF-β异型.
  • 在年轻和老年小鼠中评估了牙伤口愈合,量化了原和α11整蛋白水平.

主要成果:

  • 与年轻的捐赠者相比,老年捐赠者的纤维细胞显著减少了α11整合素和TGF-β1的表达和活性.
  • 在年轻的纤维细胞中,TGF-β1治疗增加了α11整蛋白表达,但在老年纤维细胞中没有增加.
  • 年龄较大的小鼠在牙伤口中表现出降低的原沉积,组织和较低的α11整合素和TGF-β1水平.

结论:

  • 衰老与牙纤维细胞TGF-β1表达和信号减少有关,导致α11整体蛋白表达减少.
  • 这种受损的TGF-β1依赖的α11整合素信号通路是衰老中牙结缔组织修复减弱的潜在机制.
  • 这些发现凸显了TGF-β1和α11整合素在与年龄相关的组织修复变化中的关键作用.