分数呼出的氧化用于诊断异性慢性鼻炎:系统性审查和元分析
Jae Yoon Lee1, Manal Al Ali2, Soo Whan Kim1
1Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
概括
在患有eosinophilic慢性鼻炎 (ECRS) 的患者中,分量呼出的氧化 (FeNO) 含量显著更高. 这种非侵入性生物标志物对诊断ECRS具有前景,为组织活检提供了替代方案.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 组织活检是目前用于诊断eosinophilic慢性鼻炎 (ECRS) 的标准.
- 活检的侵入性需要在门诊和手术前的环境中使用非侵入性诊断方法.
研究的目的:
- 评估微分呼出氧化 (FeNO) 作为ECRS的非侵入性诊断标记物的实用性.
- 为了比较ECRS患者的FeNO水平与非ECRS对照.
主要方法:
- 在主要数据库 (PubMed,Embase等) 进行了系统的文献搜索. 在2024年7月之前.
- 在ECRS和非ECRS患者组之间比较了FeNO水平.
- 使用ROBINS-I工具评估了偏差风险.
主要成果:
- 分析了12项涉及1159名参与者的研究.
- 在ECRS患者中,FeNO含量显著更高 (总平均差异:32.21ppb).
- 对于确定ECRS,FeNO的诊断概率比率很高 (8.78).
结论:
- 在患有ECRS的个体中,部分呼出的氧化 (FeNO) 含量显著升高.
- 作为ECRS诊断的非侵入性工具,FeNO具有很大的潜力,可以补充或可能取代侵入性活检.
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