透过颗粒看看:空气污染和肺癌的叙事审查
Darren Turner1, David Hedrick1, Sandra L Starnes1
1Division of Cardiothoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Journal of thoracic disease
|January 12, 2026
概括
细颗粒物 (PM2.5) 造成的空气污染与从不吸烟者肺癌的增加以及治疗结果的恶化有关. 减少PM2.5暴露对于公共卫生和改善患者生存率至关重要.
科学领域:
- 环境健康 环境健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 从未吸烟者中的肺癌发病率自20世纪90年代以来翻了一番,与空气污染的上升有着显著的相关性.
- 细颗粒物 (PM2.5) 是一个重要的公共卫生问题,具有已确定的致癌性质.
- 本综述侧重于流行病学证据,将PM2.5暴露与从未吸烟者的肺癌联系起来.
研究的目的:
- 综合有关PM2.5暴露与从未吸烟者肺癌发展之间的联系的流行病学证据.
- 探索驱动PM2.5诱导的肺癌的分子机制.
- 检查PM2.5暴露对非吸烟者肺癌临床结果和治疗结果的影响.
主要方法:
- 在PubMed和Scopus进行了系统的文献搜索.
- 关键词包括PM2.5流行病学和从不吸烟者的肺癌.
- 在2004年至2024年间出版的45篇相关文章从198个已识别的来源中被选中.
主要成果:
- 暴露于PM2.5会触发炎症路径 (PI3K/Akt,NF-κB,JAK/STAT,MAPK),导致氧化应激,DNA损伤和瘤突变.
- 从未吸烟者的肺癌显示出更高的EGFR突变率;PM2.5通过EGFR突变和巨细胞激活促进致癌.
- 持续暴露于PM2.5与肺癌治疗后的死亡风险增加有关,特别是在非白人群体中.
结论:
- 在从不吸烟者中增加的肺癌发病率与PM2.5空气污染的增加有关.
- 暴露于PM2.5对肺癌患者的治疗后结果产生负面影响.
- 进一步的研究对于制定减少PM2.5暴露和提高治疗结果的策略至关重要.
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