肺液神经元特异性化酶的诊断价值,用于恶性肺溢液的诊断
Xi Lin1,2, Jian-Xun Wen2,3, Yan Niu2,3
1Department of Thoracic Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Journal of thoracic disease
|January 12, 2026
概括
神经元特异性化酶 (NSE) 不是诊断恶性多叶流血 (MPE) 的可靠生物标志物. 患者队列中的心力衰竭患病率显著影响NSE.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 体液中的神经元特异性化酶 (NSE) 作为诊断生物标志物被探索.
- 现有研究表明,NSE在区分恶性流 (MPE) 和良性流 (BPE) 中的准确性不一致.
- 调查NSE诊断性能中的异质性来源至关重要.
研究的目的:
- 评估NSE的诊断准确性,以区分MPE与BPE.
- 确定影响NSE诊断绩效的诸如心力衰竭 (HF) 患病率等因素.
主要方法:
- 来自中国两个中心的未被诊断的肺流患者的潜在招生.
- 使用电化学发光测试对液NSE水平进行盲目测量.
- 通过ROC曲线,DCA和与HF患病率的相关性分析来评估诊断准确性.
主要成果:
- 在Hohhot队列中,MPE患者的NSE水平明显高于BPE患者.
- NSE的曲线下的面积 (AUC) 值为0.68 (霍霍特) 和0.65 (长沙).
- 敏感性和特异性因队列和值而异,在已发表的研究中,HF患病率与AUC正相关.
结论:
- 目前的证据不支持NSE作为MPE的有用诊断标记.
- 研究的队列中心力衰竭的患病率会影响NSE的诊断准确性.
- 需要进一步的研究来澄清NSE的作用,并解决诊断性能中的异质性.
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