婚姻状况和非小细胞肺癌死亡风险的竞争:基于SEER的诺莫格拉姆分析
Ziqiang Wang1, Tian Lan2, Yangyang Xie3
1Department of Breast Surgery, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, China.
Journal of thoracic disease
|January 12, 2026
概括
已婚非小细胞肺癌 (NSCLC) 患者的生存率更高,癌症特异性和其他原因死亡率更低. 这凸显了社会支持对NSCLC预后的重要性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 非小细胞肺癌 (NSCLC) 是全球癌症死亡的主要原因.
- 心理社会因素,如婚姻状况,可能会影响NSCLC患者的治疗结果.
- 在NSCLC中,婚姻状况对癌症特异性死亡 (CSD) 和其他原因死亡 (OCD) 的影响需要在竞争性风险框架内进一步调查.
研究的目的:
- 评估婚姻状况对NSCLC患者的CSD和OCD的影响.
- 开发和验证一种竞争性风险名谱,用于NSCLC中预测CSD.
- 使用大型的监测,流行病学和最终结果 (SEER) 数据库进行全面分析.
主要方法:
- 从SEER数据库 (2010-2015) 中分析NSCLC患者数据.
- 倾向性得分匹配 (PSM) 以平衡已婚和未婚群体之间的基线特征.
- 细灰竞争风险模型的应用,并开发一个验证的竞争风险名录.
主要成果:
- 已婚患者 (54.8%) 在PSM后显示,CSD和强迫症的累积发病率明显较低 (P<0.001).
- 未婚状态与更高的CSD风险相关 (分发危险比率=1.11;P<0.001).
- 开发的诺米图表表现出强大的预测性能 (AUC 0.81-0.84) 和良好的校准.
结论:
- 婚姻状况是NSCLC的独立预后因素,与癌症特异性和非癌症死亡率的降低有关.
- 将婚姻状况和社会支持整合到幸存者护理中,对于改善NSCLC患者的治疗结果至关重要.
- 建议进行进一步的研究,以证实研究结果,并制定支持性干预措施,以提高生存率和生活质量.
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