体重指数调解了血清纤维细胞生长因子-19和糖尿病之间的关联
Lin Liu1, Shuyun Liu2, Juanying Zhen1,3
1Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Journal of diabetes and metabolic disorders
|January 12, 2026
概括
血清纤维细胞生长因子-19 (FGF19) 的较低水平与中国成年人糖尿病风险增加有关. 身体质量指数 (BMI) 部分调解了这一关联,突出了FGF19的重点.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 生物标志物 生物标志物
背景情况:
- 纤维细胞生长因子-19 (FGF19) 与代谢调节有关.
- 了解FGF19在糖尿病中的作用对于公共卫生至关重要.
- 以前的研究表明,FGF19与代谢障碍之间存在潜在联系.
研究的目的:
- 为了研究血清FGF19水平与糖尿病之间的关联.
- 探索身体质量指数 (BMI) 在这种关系中的调解作用.
主要方法:
- 对1018名参与者的血清FGF19水平的分析.
- 逻辑回归模型用于评估糖尿病风险.
- 调解分析以量化BMI的作用.
主要成果:
- 血清FGF19水平与BMI相反相关.
- 较低的FGF19水平与糖尿病风险增加相关 (OR:0.66,95% CI:0.47-0.95).
- 体重指数占FGF19与糖尿病相关性的10.1%.
结论:
- 血清FGF19与中国人口的糖尿病风险相反相关.
- 体重指数部分调解了FGF19和糖尿病之间的关系.
- FGF19可能成为糖尿病风险的潜在生物标志物.
更多相关视频
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K


