盐水与葡萄酸盐/酸盐缓冲溶液与乳酸盐缓冲溶液对儿童血清化物的作用
Yunus Nadeemulla Beig Khader1, Sana Mehek2, Shubhanshu Gupta3
1Department of Pediatrics, Amana Healthcare, Al Ain, UAE.
Journal of pharmacy & bioallied sciences
|January 12, 2026
概括
静脉注射液的组成会影响儿科的电解质. 均衡的静脉注射液,与盐水不同,有助于保持稳定的化物水平,并可以预防儿童的酸症.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 临床化学 临床化学
- 静脉注射液体疗法是一种静脉注射液体疗法.
背景情况:
- 静脉注射 (IV) 液体是标准的儿科实践.
- 0.9%的盐水可以导致高血症,导致代谢酸和脏问题.
- 平衡的IV解决方案正在成为更安全的替代方案.
研究的目的:
- 为了比较医院住院儿童的血清化物变化,这些儿童接受盐水,葡萄糖酸/乙酸缓冲或乳酸缓冲的静脉注射液.
主要方法:
- 对90名儿科患者进行前性观察性研究.
- 患者接受了三种IV液之一:盐水 (n=30),葡萄糖酸/乙酸缓冲 (n=30) 或乳酸缓冲 (n=30).
- 血清化物在基线和24小时测量;使用ANOVA和配对t测试进行分析.
主要成果:
- 输液后的化物水平在盐水组 (107.2 ± 3.1 mmol/L) 与平衡溶液 (葡萄酸盐/乙酸盐:103.5 ± 2.4 mmol/L;乳酸盐:102.9 ± 2.8 mmol/L) 相比显著更高 (P < 0.001).
- 盐水的使用导致了最显著的化物升高.
- 在使用盐水时,观察到轻度酸化的趋势.
结论:
- 儿童使用盐水与血清化物增加的程度比平衡的IV液体更大.
- 缓冲性静脉输液在维持儿科电解质平衡方面似乎更优越.
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