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评估甲状腺下垂患者的心电图变化及其与血清TSH水平的相关性
Mahi J Khiloshiya1, Tirth H Vyas2, Ashka Priyadarshi3
1Department of Casualty, GMERS Civil Hospital, Junagadh, Gujarat, India.
Journal of pharmacy & bioallied sciences
|January 12, 2026
概括
甲状腺功能低下症与心电图的变化有关,如胸肌梗塞和延长的QTc间隔. 甲状腺刺激激素 (TSH) 水平较高的甲状腺功能低下患者与更严重的心电图 (ECG) 异常相关,突出显示需要监测.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 临床电生理学 临床电生理学
背景情况:
- 甲状腺功能低下症是一种常见的内分泌疾病,影响心血管生理学和心脏电生理学.
- 电心电图 (ECG) 异常,如心,低压复合体和延长的QT间隔,经常在甲状腺功能低下患者中观察到.
- 甲状腺功能低下症严重程度 (通过血清TSH测量) 和心电图变化之间的关系的临床相关性是显著的.
研究的目的:
- 研究甲状腺功能低下患者血清甲状腺刺激激素 (TSH) 水平和心电图 (ECG) 参数之间的相关性.
- 为了确定患有甲状腺功能低下症的个体中特定心电图异常的患病率.
- 评估由TSH水平显示的甲状腺功能低下症的严重程度是否会影响心电图变化的程度.
主要方法:
- 这是一项涉及100名年龄在20-60岁的甲状腺功能低下患者 (TSH>5.0μIU/mL) 的横截面观察研究.
- 排除标准包括先前存在的心脏疾病,电解质失衡或影响心脏导电的药物.
- 记录了心电图参数 (心率,PR,QRS,QT间隔,低压复合体) 和血清TSH水平,并对相关性进行了统计分析.
主要成果:
- 在血清TSH水平和QTc间隔 (r = 0.41,P = 0.002) 之间观察到显著的正相关性.
- 在血清TSH水平和心率 (r = -0.53,P < 0.001) 之间发现了显著的负相关性,48%的患者表现出胸.
- 包括延长QTc (36%) 和低压复合体 (22%) 在内的心电图变化在TSH水平> 10μIU/mL的患者中更为频繁.
结论:
- 甲状腺功能低下症与明显的心电图异常有关,包括胸肌梗塞和延长的QTc.
- 这些心电图异常的严重程度与血清TSH水平的增加存在相关性.
- 定期的心电图监测对于甲状腺功能低下患者,特别是高TSH患者来说,对于早期发现和治疗心脏并发症至关重要.
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