在绝经前妇女的全身麻醉后认知功能障碍和康复质量的评估

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Updated: Jan 13, 2026

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Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

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Divya Sinha¹, Nancy Ekka², Narayan Hari Sharma³

¹Department of Obstetrics and Gynaecology, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India.

Journal of pharmacy & bioallied sciences

|January 12, 2026

概括

绝经前妇女经历了显著的认知衰退,并在全身麻醉后恢复质量下降. 虽然在一周内可以看到一些改善,但认知功能和恢复并没有完全恢复到基线水平.

科学领域:

麻醉学麻醉学
神经科学是一个神经科学.
老年学是指老年学的学科.

背景情况:

绝经前期的荷尔蒙波动可以增加对神经认知变化的敏感性.
通用麻醉在绝经前妇女的认知功能中存在独特的外科手术风险.
有限的数据存在于术后认知结果和恢复质量在这个人口.

研究的目的:

研究全身麻醉对绝经前妇女认知功能的影响.
评估经过选择性手术的绝经前妇女的康复质量.
评估术后第一周内认知和功能恢复轨迹.

主要方法:

对120名绝经前妇女 (45-55岁) 进行前性观察研究.
使用迷你精神状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 在手术前和手术后的第一和第7天评估认知功能.
在手术前和手术后的第1和第7天,通过QOR-15尺度测量康复质量.

主要成果:

与基线相比,在术后第一天MMSE和MoCA得分显著下降 (P < 0.001).
认知分数在第7天有所改善,但仍低于手术前水平 (P < 0.05).
恢复质量 (QoR-15) 在术后第1天显著受损 (P < 0.001),在第7天部分恢复.

结论:

绝经前妇女在全身麻醉后经历了显著的早期术后认知功能障碍.
恢复的质量在手术后的第一时间显著下降.
在一周内无法达到完全恢复到基线水平的认知和功能恢复.

关键词:

麻醉绝经前妇女绝经前妇女认知认知能力认知能力总的来说,这是一个普遍的情况.

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