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干眼疾病中的结膜微血管变化:对Sjögren和非Sjögren亚型的比较研究

Jiyoung Emily Lee¹, Dong-Kyu Kim¹, Young Chae Yoon¹

¹Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Taiwan journal of ophthalmology

|January 12, 2026

概括

与非Sjögren干眼 (NSDE) 患者相比,Sjögren干眼 (SSDE) 患者的结膜微血管直径更大. 在NSDE中的血液动力学变化与梅博姆腺功能障碍相关,这表明干眼疾病亚型中存在明显的微血管模式.

科学领域:

眼科医生眼科眼科
微循环研究微循环研究
眼睛表面疾病眼睛表面疾病

背景情况:

结膜微血管结构的改变与眼睛和全身疾病有关.
以前的研究表明,干眼疾病 (DED) 的血液流速,速率,血管密度和直径增加.

研究的目的:

为了比较SSDE和NSDE患者与类似的DED症状之间的bulbar结膜微血管形态和血液动力学.
评估DED亚型中微血管参数和梅博姆腺功能障碍 (MGD) 之间的相关性.

主要方法:

使用专门的光学系统进行结膜成像和基于Attention-UNet的血管细分的前性研究.
已验证的两步运动校正管道应用于结膜成像数据.
使用LipiView® II进行的眼膜脂质层厚度和meibography;微血管参数的量化,包括血液流速 (BFV),血液流速 (BFR) 和直径.

主要成果:

与NSDE组 (9.431 ± 3.982 μm) 相比,SSDE组 (12.985 ± 2.478 μm) 的平均微血管直径显著更高 (P < 0.050).
在NSDE组中,血管直径与BFR呈正相关性 (P<0.050).
在NSDE组中,BFR与上部和下部梅博斯科尔正相关 (P<0.050).

结论:

独特的结膜微血管特征区分SSDE患者,血管直径作为潜在的歧视因素.
在NSDE中血液动力学变化和MGD参数之间的关联突出了MGD和结膜微循环之间的相互作用.
识别的微血管差异可以作为DED亚型分类和个性化治疗策略的生物标志物.

关键词:

泡泡结膜泡泡结膜泡泡结膜斯约格伦综合征是什么意思结节性微血管学干眼疾病是干眼的疾病.梅博姆腺功能障碍是什么

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