阿弗利塞普特,拉尼比祖马布和奥祖德克斯在治疗表现不佳反应的糖尿病黄斑 edem 的有效性:一项比较观察性研究
Otzem Chassid1,2, Karine Beiruti Wiegler3, Ala Bashir1
1Department of Ophthalmology, Ziv Medical Center, Safed, Israel.
Taiwan journal of ophthalmology
|January 12, 2026
概括
对于对贝瓦齐祖马布耐药的持续性糖尿病黄斑 (DME),静脉内抗VEGF剂和类固醇提供类似的视觉敏度和视网膜厚度改善. 然而,类固醇注射显著增加眼内压力 (IOP).
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 对抗血管内皮生长因子 (抗VEGF) 治疗的耐药性是DME管理中的一个重大临床挑战.
- 确定有效的二线治疗方法对持久性DME至关重要.
研究的目的:
- 为了比较抗VEGF药物 (aflibercept,ranibizumab) 与皮质类固醇植入物 (Ozurdex) 的疗效,作为持续性DME的二线治疗.
- 为了评估治疗后的视力敏度 (VA),中骨厚度 (CFT) 和眼内压力 (IOP) 的变化.
主要方法:
- 对60名不对贝瓦西祖马布有反应的DME患者进行了回顾性研究.
- 患者接受了三次内注射抗VEGF药物或皮质类固醇植入物.
- 收集的数据包括VA,IOP和CFT在治疗开始前和一个月后.
主要成果:
- 在第三次注射抗VEGF药物和类固醇药物后一个月观察到VA和CFT的显著改善.
- 治疗组之间没有发现临床益处的显著差异.
- 与抗VEGF药物相比,在皮质类固醇植入物治疗后,眼内压 (IOP) 显著增加.
结论:
- 内抗VEGF药物和皮质类固醇在持续性DME中提供了可比的临床益处.
- 在选择二线DME治疗时,必须考虑类固醇注射增加IOP的已知副作用.
- 进一步的研究可能会探索耐火性DME的最佳测序或组合疗法.
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