百日咳是常见的呼吸道疾病之一:一个病例报告
Jiajia Chen1, Yongchang Wu1, Jiamei Tang1
1Department of Respiratory and Critical Care Medicine, The People's Hospital of Rongchang District, Chongqing, China.
SAGE open medical case reports
|January 12, 2026
概括
成人百日咳 (百日咳) 通常呈现异常,模仿肺炎. 甲基因组测序在一个耐火病例中诊断出Bordetella pertussis,强调了在标准测试失败时的价值,并建议在抗宏化物感染时使用trimethoprim-sulfamethoxazole.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 由Bordetella pertussis引起的百日咳 (百日咳) 越来越多地被诊断为表现为非典型症状的成年人,往往导致诊断不足.
- 成年人咳可以模仿社区获得的耐火性肺炎,使诊断和治疗复杂化.
- 典型的百日咳症状,如百日咳,在成人病例中往往没有.
研究的目的:
- 报告一个模仿耐火性肺炎的成人百日咳病例.
- 在具有挑战性的病例中强调元基因组下一代测序 (mNGS) 的诊断实用性.
- 讨论抗生素治疗策略,包括潜在的宏类抗药性.
主要方法:
- 一个64岁的妇女的病例报告,持续咳和喉疼痛.
- 使用了传统的诊断方法 (和支气管支气管洗液培养物).
- 甲基因组下一代测序 (mNGS) 在支气管支气管洗液上进行.
主要成果:
- 传统测试对细菌病原体呈阴性.
- mNGS在高序列覆盖率下发现了Bordetella百日咳.
- 患者最初接受了阿齐思罗米,但没有改善,但对三甲-硫甲醇有反应.
结论:
- 长期咳不响应标准肺炎治疗的成年人应该考虑咳.
- 下一代元基因组测序是一种有价值的工具,用于在传统方法失败时诊断百日咳.
- 在Bordetella pertussis中可能会出现宏类耐药性,需要使用替代抗生素,如trimethoprim-sulfamethoxazole.
关键词:
案例报告案例报告pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis pertussis肺炎是一种肺炎.
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