一种非典型的乳杆菌jensenii Discitis和骨髓炎病例
Tarisai D Chiborise1, Tarvinder S Gilotra1
1Infectious Diseases, Catholic Health, Kenmore, USA.
Cureus
|January 12, 2026
概括
通常是无害的 Lactobacillus jensenii 在免疫功能低下的患者中引起罕见的严重脊髓感染 (脊髓炎,骨髓炎). 当标准培养物失败时,诊断需要先进的测序,突出了一个独特的乳杆菌感染病例.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床案例研究临床案例研究
背景情况:
- 乳酸菌种通常被认为是共生和有益的细菌.
- 由乳杆菌引起的感染很少见,特别是在免疫能力强的个体中.
- 严重的侵入性感染,如骨髓炎和椎间盘炎,是非常罕见的.
研究的目的:
- 报告一种罕见的Lactobacillus jensenii病例,该病例会导致腰部神经膜炎和骨髓炎.
- 突出在识别乳杆菌感染的诊断挑战.
- 为了描述复杂的乳杆菌感染的成功治疗.
主要方法:
- 一个63岁的女性患者的病例报告,她患有严重的脊髓感染.
- 通过使用下一代测序在腰部活检上确认了诊断.
- 传统的血液和组织培养对微生物生长有负面影响.
- 治疗包括六周的皮佩拉西林-塔扎巴克坦疗程,随后是阿莫西林-克拉夫兰酸盐.
主要成果:
- 牛乳杆菌 (Lactobacillus jensenii) 已被确定为腰部神经椎间盘炎和骨质炎的致病原体.
- 这种感染是由双边的psoas和肌肉炎所复杂化.
- 下一代测序在标准培养不显示时提供了明确的诊断.
- 患者经历了令人满意的临床康复,症状消失.
结论:
- 牛乳杆菌 (Lactobacillus jensenii) 可以导致严重的侵入性感染,即使没有显著的免疫性损害.
- 像下一代测序等先进的分子技术对于诊断罕见的微生物感染至关重要.
- 及时和适当的抗生素治疗可以导致复杂的乳杆菌感染的成功结果.
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