布罗利祖马布诱导的胆毛囊炎和轨道炎症:一个病例报告
Oumaima El Korno1, Zineb Hilali1, Taha Boutaj1
1Ophthalmology, Centre Hospitalo-Universitaire Ibn Sina, Hôpital des Specialités, Rabat, MAR.
Cureus
|January 12, 2026
概括
免疫检查点抑制剂 (ICI),如pembrolizumab可以引起罕见的眼部副作用. 这种病例突出了多焦点胆囊炎和后轨道病变,通过持续使用布罗利祖马布和局部类固醇成功管理.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 改善了转移性黑色素瘤的结果.
- 眼部免疫相关不良事件 (irAEs) 是罕见的,但可能威胁视力.
- 布罗利祖马布是用于治疗黑色素瘤的常用ICI.
研究的目的:
- 报告与pembrolizumab相关的罕见眼部IRE病例.
- 描述这些眼睛IRAE的临床表现和诊断结果.
- 讨论管理策略,在继续瘤治疗的同时保持视力.
主要方法:
- 一名52岁的男性患有转移性黑色素瘤,并接受了 pembrolizumab 的病例报告.
- 眼科检查包括眼底镜检查,眼底自光学 (FAF) 和绿色氨酸血管学 (ICGA).
- 轨道磁共振成像 (MRI) 用于评估轨道炎症.
主要成果:
- 患者出现了双边眼睛红色和光,视力敏度保持.
- fundus 检查显示多焦色素变化,FAF 显示低自光斑,ICGA 显示多焦色素毛囊炎.
- 轨道MRI显示后侧轨道病变与眼外肌肉扩大和脂肪炎症.
结论:
- 布罗利祖马布可以诱导罕见的眼睛irrAEs,包括多焦点胆囊炎和后轨道病变.
- 轻度的眼睛IRAE与视力保留可以通过继续 pembrolizumab与局部皮质类固醇进行管理.
- 眼科和瘤学之间的多学科合作对于最佳的患者结果至关重要.
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