关于社区对临床试验的看法的一项配对调查研究:跨医学领域塑造结果
Mallory Von Lotten1, Meredith Burns1, Passiah L White1
1Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Journal of clinical and translational science
|January 12, 2026
概括
一次简短的教育干预显著改善了代表性不足的种族群体的舒适度和愿意参与临床试验的情况. 这种方法增强了对研究过程的理解,并为各种人群提供了保护.
科学领域:
- 健康 公平 卫生 公平
- 临床试验多样性 临床试验多样性
- 社区参与科研活动
背景情况:
- 临床试验中有色人种的代表性不足是健康公平的重要障碍.
- 这种差异影响了研究的概括性和治疗结果.
- 解决这些障碍需要有针对性的干预措施来改善参与.
研究的目的:
- 评估一个简短的,以社区为中心的教育干预措施的有效性.
- 评估干预措施对代表性不足的群体对临床试验参与的看法和意愿的影响.
- 测量与试验程序的舒适度的变化,对保护的信念,以及加入皮肤相关研究的意愿.
主要方法:
- 准实验性设计被用于前后调查.
- 参与者 (N=83) 主要是黑人 (90.5%) 和女性 (88.4%).
- 与Bonferroni校正配对的t测试分析了30分钟的教育课程 (虚拟和面对面) 后调查答案的变化.
主要成果:
- 参与者在临床试验参与后的舒适度有显著改善 (p < 0.05).
- 在临床试验期间,人们对临床试验所提供的保护的信心增加 (p < 0.05).
- 参与临床试验的意愿,包括那些专注于皮肤疾病的临床试验,显著改善 (p < 0.05).
结论:
- 简短的,以社区为基础的教育干预可以有效地提高对临床试验参与的理解和积极态度.
- 这种计划有望增加代表性不足的种族群体在研究中的参与.
- 有针对性的教育推广是促进临床研究中的健康公平的可行策略.
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