蛋白质和氨基酸补充对慢性心力衰竭患者的身体表现的影响 - - 系统性审查和元分析
Hirotada Maeda1, Yasuyuki Kurasawa2, Yuto Fujita1
1Department of Rehabilitation, Kanazawa Medical University Hospital Ishikawa Japan.
Circulation reports
|January 12, 2026
概括
蛋白质和氨基酸补充剂显著改善慢性心力衰竭 (CHF) 患者的身体表现. 在老年人和无法运动的人群中观察到益处,尽管证据质量较低.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 运动生理学 运动生理学
背景情况:
- 慢性心力衰竭 (CHF) 与减少体力表现有关.
- 正在探索营养干预措施,以改善CHF患者的治疗结果.
研究的目的:
- 评估蛋白质和氨基酸补充对心血管衰竭患者身体表现的影响.
- 综合关于这个主题随机对照试验 (RCT) 的证据.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2024年8月.
- 包括15个RCT与744名参与者,比较补充剂与安慰剂或常规护理.
- 主要结局是用6分钟步行距离 (6MWD) 测量体力表现.
主要成果:
- 与对照组相比,蛋白质和氨基酸补充剂显著改善了6MWD35.25米 (95%CI15.93-54.58).
- 亚组分析表明,单独补充与与运动结合的补充具有类似的益处.
- 65岁及以上的患者表现出类似的改善.
结论:
- 蛋白质和氨基酸补充剂可以提高CHF患者的体力表现.
- 补充可能对老年人或有运动限制的人特别有益.
- 目前证据的整体质量被认为非常低.
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