在听觉口头幻觉中,前中枢环连接性:休息状态功能性MRI研究
Vyara Zaykova1, Ferihan Popova1, Sevdalina Kandilarova2
1Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Alpha psychiatry
|January 12, 2026
概括
精神分裂症患者有听觉口头幻觉,在前中心环中显示出大脑连接的改变. 这些功能连接 (FC) 变化,特别是在右前中心 (PCG) 中,可能表明与精神分裂症相关的神经生物学途径.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症是一种复杂的精神障碍.
- 听觉语言幻觉 (AVH) 是一个常见的症状.
- 了解AVH的神经基础至关重要.
研究的目的:
- 在精神分裂症患者中研究前中心 (PCG) 的功能连接性 (FC).
- 为了比较患者和健康对照 (HC) 之间的FC模式.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 105名受试者参加了这项研究:42名精神分裂症患者患有AVH,63名HC患者.
- 对双边PCG FC进行了比较分析.
主要成果:
- 在患者与HC之间增加了右PCG和额叶皮层之间的FC,SMA和ACC.
- 在患者中,右PCG和舌/部区域之间的FC降低.
- 对左PCG也观察到改变的FC模式,显示特定大脑区域的连接性增加和减少.
结论:
- 精神分裂症患者在PCG功能连接中表现出横向性损伤.
- 这些FC变化可能有助于精神分裂症和幻觉倾向的神经生物学.
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