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生活方式行为,血清代谢物和高近视:孟德尔的随机化和调解分析

Nian-En Liu^1,2, Xiao-Tong Xu^3,4,5, Xiao-Bing Yu¹

¹Department of Ophthalmology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

International journal of ophthalmology

|January 12, 2026

概括

适度的体力活动和户外时间可以降低高近视 (HM) 风险. 脂质代谢物调解体育活动的保护作用,这表明HM预防的目标. 需要进一步的研究.

科学领域:

眼科医生眼科眼科
遗传学遗传学是一个
代谢学代谢学代谢学

背景情况:

高近视 (HM) 是一个日益严重的公共卫生问题.
了解HM的因果因素和媒介对于预防策略至关重要.

研究的目的:

调查行为因素 (屏幕时间,教育,户外时间,体力活动) 与HM风险之间的因果关系.
通过使用孟德尔随机化 (MR) 和调解分析,确定血清代谢物在这些关联中的潜在调解作用.

主要方法:

用单变量和多变量门德尔随机化 (MR和MVMR) 分析来评估因果关系.
血清代谢物的全基因组关联研究 (GWAS) 总结统计数据被用于调解分析.

主要成果:

增加户外时间和适度的体力活动与降低HM风险有关.
适度的体力活动显示出对HM的独立保护作用.
13种血清代谢物,包括12种脂质和1种氨基酸衍生物,与HM有显著关联.
六种脂质代谢物调解了身体活动对HM的保护作用,其中1 - - - 棕) - GPC显示了最高的调解比例 (30.83%).

结论:

适度的体力活动,与户外时间一起,提供了对高近视的独立保护作用.
脂质代谢物是预防HM的关键媒介和潜在目标,特别是在身体活动较低的个体中.
这些发现强调了体力活动和代谢健康在高近视病因方面的重要性.

关键词:

高近视的高近视是一个问题.调解分析调解分析多变量门德尔式随机化身体活动身体活动血清代谢物的血清代谢物.

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