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乳酸可以通过调节热和线粒细胞衰变来保护肠道免受辐射引起的损伤

Wenyue Shan¹, Wei Wei¹, Yuqi Zhang¹

¹State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China. zhaolin.0000@163.com.

Food & function

|January 12, 2026

概括

乳酸铁素 (Lf) 通过促进线粒细胞衰变和抑制热死来防止辐射诱导的肠损伤. 这项研究表明,Lf促进受损线粒体的清除,减少炎症和细胞死亡.

科学领域:

细胞生物学细胞生物学
辐射瘤学辐射瘤学
胃肠病学胃肠病学

背景情况:

辐射诱导的肠损伤 (RIII) 涉及热和线粒细胞失衡.
乳酸 (Lf) 具有抗氧化和抗炎性质,但其在RIII中的作用尚不清楚.

研究的目的:

调查Lf对RIII的保护作用.
阐明Lf对热致死和线粒的作用背后的机制.

主要方法:

在体外:大鼠IEC-6细胞暴露于4GyX射线辐射.
在体内:雄性C57BL/6J小鼠接受了10 Gy的全腹部辐射.
评估了ROS,烧亡 (NLRP3/caspase-1/GSDMD) 和线粒的途径 (PINK1/Parkin,FUNDC1/BNIP3/NIX). 通过这些途径,我们可以测量细胞的死亡率.

主要成果:

辐射诱导的热和线粒体功能障碍.
如果预处理降低了ROS,抑制了热,并在被辐射的细胞和小鼠中激活了mitophagy.
Lf诱导的线粒包括依赖于无素的和独立的途径.
通过Lf缓解RIII取决于线粒细胞的激活.

结论:

乳托费林通过增强线粒细胞和抑制热死来减轻辐射诱导的肠损伤.
Lf促进受损线粒体的早期清除,从而抑制NLRP3炎症酶激活.
这些发现强调Lf作为RIII的潜在治疗剂.

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