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HMGB2-RAD21轴促进纤维/脂肪原生原始细胞的扩散,并调节脂肪透

Xian Tong¹, Ziyun Liang¹, Tianqi Duo¹

¹State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 12, 2026

概括

研究人员确定了一种特定的细胞亚群,HMGB2+纤维/基原生细胞 (FAPs+),对于调节肌肉中的脂肪细胞数量至关重要. 这一发现提供了有关肉质和骨肌肉健康的见解.

科学领域:

肌肉生物学肌肉生物学
增脂生殖是一种增脂的过程.
发育生物学是发展生物学.

背景情况:

肌肉间脂肪 (IMF) 透会影响肌肉健康和肉质.
控制肌肉间脂肪细胞丰富性的细胞机制尚未完全理解.
猪肌肉中的前脂肪细胞分化在产后开始,这表明胚胎因素是关键因素.

研究的目的:

调查胚胎阶段调节纤维/基原体 (FAP) 数量的发育机制.
为了确定影响肌肉间脂肪细胞丰富性的关键细胞参与者.
探索管理国际货币基金组织内容的潜在治疗目标.

主要方法:

胚胎猪肌肉的单细胞RNA测序 (ScRNA-seq) 进行.
FAP亚群的识别和表征.
在小鼠中进行基因淘汰研究 (HMGB2).
分析FAP的扩散和差异化潜力.

主要成果:

构建了第一个胚胎FAP的发育地图.
一个独特的HMGB2表达FAP亚群 (FAPs^HMGB2+) 被确定为FAP池大小的关键.
在小鼠中HMGB2缺乏导致FAP数量减少和脂肪生成受损.
在体内,HMGB2通过向RAD21,一种DNA复制基因来调节FAP的增殖.

结论:

在发育和再生过程中,HMGB2是FAP增殖和肌肉间脂肪细胞丰富度的关键调节者.
准HMGB2为改善猪肉质量和解决骨肌肉中的病态脂肪透提供了一个潜在的战略.

关键词:

在HMGB2中,它是HMGB2.亚迪波基因分化的差异化.纤维/基原始体的祖先.肌肉间脂肪肌肉间脂肪一个单细胞RNA测序.

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