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在癌症新陈代谢和免疫治疗中向乳酸盐和乳糖化

Jiajing Gong¹, Yuhang Xie¹, Zhijie Weng¹

¹State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 12, 2026

概括

乳酸盐,曾经只是一种副产品,现在已知可以通过代谢重编程和乳酸化驱动癌症生长和免疫逃避. 针对乳酸代谢和乳糖化提供了有前途的新癌症免疫治疗策略.

科学领域:

在瘤学瘤学.
癌症新陈代谢癌症新陈代谢
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

乳酸是癌症代谢的关键调节剂,通过华堡效应推动癌症的扩散.
增加的乳酸盐形成了一个免疫抑制瘤微环境 (TME),促进癌症的进展和转移.
乳酸化是一种翻译后的修改,揭示了乳酸作为一种信号分子,将新陈代谢和基因调节联系在一起的作用.

研究的目的:

审查乳酸和乳化在癌症生物学中的多方面的作用.
探索乳酸如何影响癌症恶性,包括扩散,转移,耐药性和免疫逃避.
讨论乳酸驱动乳化在代谢和表观遗传控制中的整合.

主要方法:

关于乳酸盐在癌症代谢和信号传递中的作用的文献综述.
分析乳酸和乳化对瘤微环境的影响.
针对乳酸代谢和乳酸酶化的新兴治疗策略的摘要.

主要成果:

乳酸盐积极促进癌症恶性,包括扩散,转移,耐药性和免疫逃避.
乳酸驱动的乳化桥梁代谢重编程与表观遗传修饰.
向乳酸代谢和乳糖化显示出增强癌症免疫疗法的潜力.

结论:

乳酸是癌症进展和免疫规避的关键媒介.
乳糖化是将癌症代谢与基因调节相结合的关键机制.
针对乳酸和乳酸化治疗的治疗策略对癌症治疗中的临床应用具有重大前景.

关键词:

癌症癌症癌症癌症癌症乳酸乳酸是一种乳酸.乳化乳化乳化代谢代谢代谢代谢瘤微环境 (TME) 是指瘤的微环境.

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