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在中国 (1961-2024) 侵袭性非伤寒型沙门氏菌感染:对多中心病例报告的回顾性系统分析

Haiyang Zhou^1,2, Chenghao Jia³, Qianzhe Cao¹

¹Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, China.

Journal of global health

|January 12, 2026

概括

侵袭性非伤寒型沙门氏菌 (iNTS) 感染在中国越来越令人担忧,东部地区是热点地区. 该研究强调了关键的风险因素和显著的病例死亡率,强调了需要更好的监测.

科学领域:

流行病学流行病学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

侵袭性非伤寒型沙门氏菌 (iNTS) 感染对全球健康构成重大挑战,特别是在低收入和中等收入国家.
有一个显着的缺乏系统分析关于在亚洲的负担和 iNTS的流行病学,特别是在中国.
iNTS感染不同于伤寒型沙门氏菌,通常会导致更严重的侵入性疾病.

研究的目的:

系统地分析中国侵袭性非伤寒型沙门氏菌 (iNTS) 感染的负担和流行病学特征.
确定与中国iNTS相关的时空分布模式,患者人口统计和临床结果.
确定中国人口中 iNTS 的总体病例死亡率.

主要方法:

在多个数据库 (Web of Science,PubMed,CNKI,Wanfang,Airiti,CSTJD) 进行了全面的文献搜索,截至2024年3月31日.
主要结局包括时空分布,患者特征和INTS病例的临床结局.
二次结果涉及隔离特征,病史和药物使用,使用Open Meta-Analyst软件估计病例死亡率.

主要成果:

对199个出版物的分析显示,中国东部是INTS感染的热点.
男性和儿童被确定为易受感染的人群,创伤和代谢疾病是主要的风险因素.
最常见的血清病毒是Typhimurium,Choleraesuis和Enteritidis,血流入侵是常见的. 总体病例死亡率为8.6%.

结论:

在中国,iNTS的流行病学趋势与患者特征和病原体因素有关.
迫切需要加强中国iNTS的监控系统.
地理定制的干预措施至关重要,特别是在欠发达地区,以减轻iNTS的影响.

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