晚期发病的风湿性关节炎和多民族队列中的空气污染
Anna H Wu1,2, Chiuchen Tseng1, Song-Yi Park3
1Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Arthritis & rheumatology (Hoboken, N.J.)
|January 12, 2026
概括
环境空气污染,特别是细颗粒物 (PM2.5$) 和二氧化 (NO2$),与老年人中风湿性关节炎 (RA) 发病率的增加有关. 对于非裔美国人和拉丁裔个人来说,这些风险明显更高.
科学领域:
- 环境健康 环境健康
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
- 对环境空气污染的暴露越来越被认为是各种健康状况的潜在环境风险因素.
- 在RA发病率和严重程度方面存在种族和民族差异.
研究的目的:
- 研究环境空气污染与多样化的老年人群中类风湿性关节炎 (RA) 发病率之间的关联.
- 探索跨种族和种族群体之间这些协会的潜在差异.
主要方法:
- 来自加利福尼亚多民族队列 (MEC) 医疗保险数据 (2001-2018) 的65岁以上42,152名参与者的分析.
- 使用多变量Cox比例危险回归与时变的空气污染物数据从时空模型.
- 调整为人口统计学,社区社会经济地位,吸烟和职业暴露.
主要成果:
- 增加的RA发病率与暴露于细颗粒物 (PM$_{2.5}$) 和二氧化 (NO$_{2}$) 相关.
- 与日裔美国人和白人成年人相比,在非洲裔美国人和拉丁裔成年人中观察到更高的风险关联.
- PM$_{2.5}$与RA之间的关联在男性和高风险职业暴露的人群中更强.
结论:
- 环境空气污染,包括PM和气体污染物,与65岁以上成年人患RA的发病率较高有关.
- 这些发现强调了空气污染在加剧RA风险中的种族和民族差异方面的潜在作用.
- 需要进一步的研究才能充分理解空气污染对RA差异的贡献.
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