第三代后果 怀孕年龄较小的婴儿出生
James W Collins1, Tanvi Batish2, S J Cavé Doi3
1Division of Neonatology-#45, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL, 60611, USA. jcollins@northwestern.edu.
Maternal and child health journal
|January 12, 2026
概括
对于妊娠年龄 (SGA) 来说出生小的女性在孙子中SGA出生率略高. 这种代际效应在美国城市人口中观察到,特别是在非洲裔美国人中.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 跨代健康研究跨代健康研究
背景情况:
- 对于妊娠年龄来说小 (SGA) 是不良围产期结果的重要指标.
- 了解代际健康模式可以为预防策略提供信息.
- 以前的研究已经探索了出生结果中的家族联系,但跨代SGA传播需要进一步调查.
研究的目的:
- 为了确定是否美国出生的女性,他们自己出生时的妊娠年龄 (SGA) 较小,在他们的孙子中表现出SGA的比率更高,而不是SGA女性.
- 调查母亲SGA地位对孙子出生结果的潜在跨代影响.
主要方法:
- 采用多步链接策略,将芝加哥出生的婴儿 (2005-2017) 的重要记录与他们的母亲 (1989-1991) 和母亲的祖母 (1956-1976) 连接起来.
- 根据性别特异性体重对妊娠年龄百分比使用基于人口的参考来定义SGA.
- 采用分层和多变量逻辑二项式回归分析,计算人口归因风险 (PAR).
主要成果:
- 与非SGA妇女 (17.6%) 相比,SGA出生的妇女在孙子中SGA出生的发病率较高 (23.3%),相对风险 (RR) 为1.30.
- 调整后的分析,控制共变量,显示前SGA女性中孙子SGA的RR增加了1.22.
- 非洲裔美国人中,母亲祖母的SGA身份占SGA分娩的4.3%.
结论:
- 在美国,SGA出生女性在孙子中SGA出生频率略有增加.
- 这些发现表明SGA的跨代组件,在非洲裔美国人群中尤其显著.
- 一小部分SGA出生可以归因于母亲祖母的SGA地位.
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