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Updated: Jun 27, 2026

Molecular Probe Optimization to Determine Cell Mortality in a Photosynthetic Organism Microcystis aeruginosa Using Flow Cytometry
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解开子:优化奥罗拉A的准PROTACJB170到CCT400028,一个In Vitro降解化学探测器

Jack A O'Hanlon1,2, Katrin Gutsche1, Juliane Elisabeth Müller3

  • 1Centre for Cancer Drug Discovery, The Institute of Cancer Research, London SM2 5NG, U.K.

Journal of medicinal chemistry
|January 12, 2026
PubMed
概括

我们开发了CCT400028,一个改进的Aurora A PROTAC,克服了诸如效应和不稳定性等局限性. 这种新的化学探测器使得在体外研究中具有强大和选择性的Aurora A降解.

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相关概念视频

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...