心脂肪与Fontan手术后患者的心室扩张有关
Meghan D Ryan1, Nicole St Clair2, Christine K Lee3
1Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA. meghan.ryan@childrens.harvard.edu.
Pediatric cardiology
|January 12, 2026
概括
身体脂肪,特别是上心脏和肝脏脂肪,与Fontan患者的心脏重塑有关. 较高的身体质量指数 (BMI) 强烈相关于心上脂肪质量增加和肝硬化,独立于临床事件.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脊心和肝脏脂肪积累与心脏重塑有关.
- 芬坦手术是单心室缺陷的缓解手术,可导致长期心血管并发症.
- 了解Fontan幸存者的脂肪分布和心脏参数之间的关系对于风险分层至关重要.
研究的目的:
- 为了确定心脏磁共振 (CMR) 成像参数与索引心上脂肪质量 (EFMi) 和肝硬化症相关的患者在Fontan手术后.
- 探索身体质量指数 (BMI) 和这些脂肪储存之间的相关性.
- 评估EFM和肝肥胖症与不良临床结果的关联.
主要方法:
- 对82名Fontan患者的回顾性分析.
- 使用CMR后处理软件 (cvi42) 量化表皮和皮下脂肪.
- 通过使用过渡性弹性素学对控制衰减参数 (CAP) 评分来评估肝肥胖症.
主要成果:
- 索引表心脂肪质量 (EFMi) 与BMI,年龄,末缩体积指数 (ESVi),末腹缩体积指数 (EDVi),心室质量指数,皮下脂肪厚度,射出分数和下静脉腔 (IVC) 流量指数具有显著的单变相关性.
- 多变量分析显示BMI和EDVi作为EFMi的独立预测因素.
- 控制减弱参数 (CAP) 评分与BMI,皮下脂肪厚度,皮下脂肪质量指数,年龄,EFMi和心室质量指数显著相关.
- 线性回归确定BMI是CAP分数的唯一独立预测因素.
- 无论是EFMi还是CAP分数都没有与不良临床事件有显著的关联.
结论:
- 身体质量指数 (BMI) 是Fontan幸存者的心上和肝脏脂肪积累的强有力的决定因素.
- 心上脂肪质量的增加与这个人群中的心室扩张有关.
- 虽然脂肪积累与心脏参数有关,但在这个队列中,它与不良临床事件没有相关性.
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