没有明显的母体ZIKV感染会影响胎儿大脑发育和产后行为
Tsui-Wen Chou1, Micheal McCourt1, Eduard Marmut1
1Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, United States of America.
PLoS pathogens
|January 12, 2026
概括
即使是轻微的母体寨卡病毒 (ZIKV) 感染,也会在后代中引起微妙的长期神经变化. 这项研究揭示了小鼠的分子和行为变化,强调需要监测暴露在子宫中的儿童.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 发展生物学 发展生物学
背景情况:
- 寨卡病毒 (ZIKV) 与严重的婴儿神经问题有关,如小头症和先天性寨卡综合征 (CZS).
- 温和或不明显的母体ZIKV感染的长期神经效应尚不清楚.
研究的目的:
- 用人类STAT2敲入小鼠模型研究孕期中期母亲ZIKV感染对胎儿神经发育的影响.
- 为了确定在无症状的母亲ZIKV暴露后后代的分子和行为变化.
主要方法:
- 在妊娠中期hSTAT2小鼠中发生的母性ZIKV感染.
- 胎儿大脑组织的转录分析.
- 在海马体中评估突触密度.
- 化学诱导的发作敏感性测试.
- 使用运动测序 (MoSeq) 对自发行为的无监督机器学习分析.
主要成果:
- 母亲的ZIKV感染导致垂直传播,在母体或后代中没有明显的临床症状.
- 观察到与突触功能和神经元发育相关的胎儿大脑基因表达的显著变化.
- 后代表现出海马突触密度增加和发作易感性增加.
- 在后代中检测到自发运动行为的持久性,性别偏差的改变.
结论:
- 轻微的母亲ZIKV感染可以导致后代微妙但显著的长期神经后果.
- 这些发现强调了监测子宫内暴露于ZIKV的儿童的重要性,即使没有严重的分娩结果.
- 这项研究提供了一个有价值的模型和数据集,用于进一步研究不明显的母亲ZIKV感染影响.
更多相关视频
09:18Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
Published on: September 19, 2017
11.0K
09:39Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
Published on: April 26, 2018
9.1K
相关概念视频
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:22Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...