医疗保健工作者夜班工作和乳腺癌风险:系统性审查和元分析
G Esposito1, F Bravi1, C Santucci1,2
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, 20133 Milan, Italy.
Occupational medicine (Oxford, England)
|January 12, 2026
概括
夜班工作可能会增加医疗保健工作者患乳腺癌的风险,特别是长期暴露. 然而,该协会需要进一步调查才能最终确定.
科学领域:
- 职业健康 职业健康 职业健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 医疗保健工作者 (HCW) 经常从事夜班工作.
- 夜班工作是增加癌症发病率的潜在危险因素.
研究的目的:
- 进行系统审查和元分析.
- 调查夜班工作与HCWs乳腺癌风险之间的联系.
主要方法:
- 在PubMed/Embase的系统文献搜索.
- 对包含的研究进行偏差风险评估.
- 使用随机效应模型来估计聚合相对风险 (RR) 的元分析.
主要成果:
- 分析了12项涉及12132例乳腺癌病例的研究.
- 建议使用剂量与反应的关系,较长时间的夜班工作 (例如,≥20年) 具有更高的RR.
- 显著的局限性包括高风险的偏见在曝光表征和潜在的出版偏见.
结论:
- 长期夜班工作可能与HCWs的乳腺癌风险增加有关.
- 目前的证据尚未确定,需要进一步进行强有力的研究.
- 如果这种联系得到证实,夜班工作可能会占这一群体中乳腺癌病例的很大一部分.
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