定期的禁食和再养重新塑造了棕色脂肪组织中的脂质和,储存和分布
Xing Zhang1,2,3,4, Ting Jiang5,6, Chunqing Wang1
1Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
棕色脂肪组织 (BAT) 通过改变其脂肪酸概况和脂质和度来适应禁食和再养. 这种由mTORC1调节的新陈代谢重编程对于能量恒温至关重要.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 脂肪组织生物学 脂肪组织生物学
- 营养物质感应 营养物质感应
背景情况:
- 棕色脂肪组织 (BAT) 对于能量平衡至关重要,处理各种营养素.
- 适应BAT的禁食和再养周期的理解仍然不充分.
研究的目的:
- 在禁食和再养期间调查BAT的代谢适应.
- 阐明mTORC1在BAT对营养可用性变化的反应中的作用.
主要方法:
- 使用液体色谱 (LC),毛细电泳 (CE) 和空间分辨率成像.
- 在BAT和白色脂肪组织 (WAT) 中分析了自由脂肪酸 (FFA) 和脂质配置文件.
- 研究了替代性禁食 (ADF) 和反对脂质代谢和mTORC1信号的影响.
主要成果:
- 最佳技术表现出独特的FFA和与脂质结合的FA概况,富含非常长链多不和脂肪酸 (VLC-PUFA).
- 在BAT中,ADF诱导了动态的FFA变化,并改变了上层糖解,糖生成和甘油三合成.
- 重新养导致BAT从不和脂质转变为和脂质,这一过程取决于mTORC1的激活.
结论:
- 随着禁食和再养,BAT经历了显著的脂质和和空间重编程.
- 在营养物质波动期间,mTORC1信号传递是BAT适应性脂质代谢的关键调节器.
- 这些发现为BAT在新陈代谢平衡中的适应作用提供了新的见解.
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