在外科手术期间选择抗生素和尿路感染在缩手术中
Margot Le Neveu1,2, Charlie Toman3, Stephen Rhodes1
1Urology Institute, University Hospitals/Cleveland Medical Center.
Urogynecology (Philadelphia, Pa.)
|January 12, 2026
概括
与 gentamicin 加上 clindamycin (GC) 相比,以塞法林为基础的抗生素可以减少盆腔器官脱落 (POP) 手术后尿路感染 (UTI) 的并发症. 这一发现有助于为POP患者选择最佳的外科手术期间抗生素治疗方案,以预防手术后的尿路感染.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 尿路感染 (UTI) 是骨盆器官缩 (POP) 手术后的常见并可预防的并发症.
- 最佳的术后抗生素选择对于尽量减少POP患者的术后并发症至关重要.
研究的目的:
- 在接受POP手术的患者中,根据接受的周围手术抗生素治疗方案,比较医院的术后尿路感染率.
- 评估塞法林 (C),珍塔米辛+克林达米辛 (GC) 和塞法林+美트로尼达 (CM) 疗法在预防尿路感染方面的疗效.
主要方法:
- 从2000年到2022年,对166,673名接受POP手术的患者进行了回顾性队列分析.
- 主要结局:术后30天内发生的尿路感染. 二次结果:在90天内访问急诊室,住院患者和尿路感染.
- 用于控制混手术前因素的治疗权重的逆概率 (IPTW).
主要成果:
- 整体30天术后尿路感染率为3.0%.
- 与基于塞法林的疗法相比, جنتamicin + clindamycin (GC) 疗法与90天尿路感染,尿路感染相关的ED访问和住院病例的显著增加有关.
- 在IPTW之后,GC仍然与30天尿路感染 (OR,1.27),90天尿路感染 (OR,1.30),尿路感染相关的ED访问 (OR,1.40) 和住院患者入院 (OR,1.36) 的几率增加有关.
结论:
- 与 gentamicin + clindamycin 治疗方案相比,基于塞法林的抗生素治疗方案在POP 手术后与住院的尿路感染相关并发症的概率较低.
- 这些发现支持使用以塞法林为基础的抗生素来预防POP手术患者的尿路感染.
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