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通过聚合器旋转治疗减轻眼睛扭曲诱导的边缘损失在眼睛质子疗法通过聚合器旋转

Harris Hamilton¹, Daniel Björkman², Antony John Lomax³

¹University of Glasgow College of Science and Engineering, James Watt South Building, University of Glasgow, Glasgow, G12 8QQ, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Physics in medicine and biology

|January 12, 2026

概括

质子疗法中的眼可以减少治疗边缘. 与眼睛扭转 (NTM) 调整对齐对比器旋转保留了61%的边际,患者特定的适应为眼睛质子疗法提供了进一步的改进.

科学领域:

眼科医生眼科眼科
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

眼睛扭转,眼睛的旋转,在眼睛质子疗法 (OPT) 中提出了挑战.
这种旋转可能会损害安全边缘,并降低剂量符合目标.
调查眼睛扭曲的影响对于优化OPT输送至关重要.

研究的目的:

在OPT中量化眼睛扭曲对侧边缘的影响.
探索和验证量化适应策略,以减轻因眼睛扭曲而导致的边际损失.
评估不同聚合器旋转策略在补偿眼睛扭转方面的有效性.

主要方法:

模拟使用OCULARIS进行,OCULARIS是一个内部的OPT研究规划工具.
14名接受OPT的患者被分析,模拟的眼睛扭转角度从-8°到8°.
在每个扭转角度模拟了19次对冲器旋转,以确定边缘效应.

主要成果:

随着眼睛扭曲的增加,边际损失升级,显示出受目标形状影响的患者间显著的变化.
调整对准器旋转与眼扭动 (NTM) 保持了61%的利率.
针对患者的具体调整和回归方法 (聚合器旋转=扭转角度-1°对于>2°扭转) 显示了剂量一致性的改善.

结论:

眼睛扭转导致边缘损失,患者的几何形状显著影响了这种损失的程度.
在NTM的聚合器旋转策略有效地弥补扭转引起的边缘损失.
研究了替代策略,包括优化的聚合器旋转框架,用于管理OPT中的眼扭.

关键词:

眼内瘤是眼内瘤的一种.辐射疗法辐射疗法治疗计划治疗计划

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