在1型糖尿病患者中使用连续葡萄糖监测的妊娠结果
Shannon McCloskey1, Joseph Biggio2, John Morgan1
1Maternal Fetal Medicine, Ochsner Clinic Foundation, New Orleans, United States.
American journal of perinatology
|January 12, 2026
概括
持续血糖监测 (CGM) 在1型糖尿病 (T1DM) 怀孕中改善了血糖控制,但并没有持续改善临床结果. 更严格的CGM目标与更好的血糖控制和更少的早产有关.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 糖尿病研究研究 糖尿病研究
背景情况:
- 持续血糖监测 (CGM) 与1型糖尿病 (T1DM) 中更好的血糖控制有关.
- 然而,它对非血糖结果的影响,特别是在怀孕期间,需要进一步调查.
- 现实世界的数据对于了解CGM在T1DM怀孕中的全部效果至关重要.
研究的目的:
- 评估CGM在T1DM怀孕中的使用是否在现实环境中改善了血糖和临床结果.
- 为了将CGM用户与传统血糖监测患者进行比较.
- 探索CGM目标设置与怀孕结果之间的关联.
主要方法:
- 从2016年到2023年对288名T1DM患者进行了回顾性队列研究.
- 主要结局:第二季度中期的HbA1c<6%和严重的孕产妇发病率,孕前,早产 (<34周),糖尿病酸性脂肪酸的复合.
- 使用多变量逻辑回归来计算调整的赔率比率 (aOR).
主要成果:
- 使用CGM与第二季度中期改善的血糖控制相关 (40.7%vs17.5%,aOR2.32).
- 在CGM和传统监测组之间的复合结果中没有发现显著差异 (42.8%与49.0%,aOR0.70).
- 在CGM组中,更严格的目标与更好的血糖控制,减少早产 (aOR 0.16) 和减少NICU入院 (aOR 0.37) 相相关.
结论:
- 在T1DM怀孕中使用CGM可以改善血糖控制,但并不总是转化为更好的临床结果.
- 遵守美国糖尿病协会 (ADA) 的血糖目标可能是一个关键因素.
- 更严格的CGM目标显示出改善血糖控制和T1DM怀孕的特定临床结果的希望.
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