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和多醇基物质 (PFAS) 改变 THP-1 人类单细胞的免疫反应

Jennifer R McCall¹, Kathryn T Sausman¹, Ralph N Mead²

¹School of Nursing, College of Health and Human Services, University of North Carolina Wilmington, 601 S. College Road, Wilmington, NC, USA; Center for Marine Science, University of North Carolina Wilmington, 5600 Marvin K Moss Lane, Wilmington, NC, USA.

Environmental toxicology and pharmacology

|January 12, 2026

概括

和多醇基物质 (PFAS) 对人类免疫细胞的影响不同. 这项研究揭示了各种PFAS如何改变免疫反应,影响细胞因子释放和细胞激活状态,即使度低.

科学领域:

环境健康科学环境健康科学
免疫毒理学免疫毒理学
细胞生物学细胞生物学

背景情况:

和多基物质 (PFAS) 是普遍存在的环境污染物.
暴露于PFAS与不良健康结果有关,包括免疫系统功能障碍.
通过PFAS影响免疫功能的精确细胞机制尚未完全理解.

研究的目的:

研究各种 PFAS 对 THP-1 人类单细胞功能的直接体外影响.
阐明不同的PFAS化合物如何差异调节免疫细胞反应.
了解PFAS诱导的免疫改变背后的细胞机制.

主要方法:

在体外研究中利用了THP-1人类单细胞细胞系.
细胞暴露于特定的PFAS,包括遗留 (PFOA,PFOS),副产品 (NBP2) 和下一代 (HFPO-DA/"GenX") 化合物.
评估免疫细胞激活,细胞因子概况和表型标记物的变化.

主要成果:

所有测试的PFAS激活了THP-1细胞并改变了免疫功能.
PFOS抑制了炎症性细胞因子的释放.
NBP2和PFO4DA诱导混合的炎症和抗炎反应.
PFOA,HFPO-DA/"GenX"和PFMOAA促进了抑制性表型,类似于与瘤相关的巨细胞.

结论:

即使在非致命度下,PFAS也会直接干扰免疫细胞的功能.
不同的PFAS化合物对免疫反应产生不同的,往往相反的影响.
这些发现突显了PFAS复杂的免疫调节潜力,影响了细胞因子概况和免疫激活状态.

关键词:

在HFPO-DA/GenX中使用.一个单细胞单细胞.纳菲昂副产品 2 副产品在PFAS中,有很多方法.在PFMOAAAA中.在PFO4DA中,我们可以使用PFO4DA 这就是PFOA的PFOA.在PFOS系统中,我们可以这就是THP-1的特点.免疫抑制是一种免疫抑制.这是一种炎症性炎症.

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