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通过可溶性RAGE揭露营养不良:来自FRASNET的生物标志物指导的洞察力

Sarah Damanti¹, Clara Sciorati², Amanda Avola²

¹Vita Salute San Raffaele University, Milan, Italy; Internal Medicine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Experimental gerontology

|January 12, 2026

概括

高水平的高级糖化终产品 (sRAGE) 溶解受体与老年人营养状况较差有关. 这一发现表明,sRAGE可能有助于识别营养不良风险,特别是在女性中.

科学领域:

老年医学老年医学
营养科学营养科学
生物标志物研究生物标志物研究

背景情况:

营养不良是一种常见的老年综合征,具有严重的健康后果.
炎症在营养下降中起作用,但传统标记物往往不敏感.
高级糖化终产品 (sRAGE) 的溶性受体是疾病风险的新兴生物标志物.

研究的目的:

调查循环sRAGE水平与社区老年人营养状况之间的关联.
确定sRAGE是否可以作为老年人群营养不良风险的生物标志物.

主要方法:

在FRASNET队列中,对52名社区老年人的前性观察研究.
在两个时间点评估血清sRAGE水平和营养状况 (迷你营养评估简单表格).
线性回归和ROC曲线分析以评估关联和诊断性能.

主要成果:

较高的基线sRAGE水平与较低的BMI,减少的小腿周长和较差的MNA-SF得分相关.
这些关联在女性中更为显著.
ROC分析显示,营养不良风险的诊断准确度很好 (AUC = 0.85),最佳的sRAGE切线为1362.5 pg/mL.

结论:

较高的sRAGE水平有望与老年人,特别是女性的不良营养结果有关.
sRAGE显示出作为早期检测与炎症相关的营养不良风险的有价值工具的潜力.

关键词:

生物标志物生物标志物营养不良营养不良营养不良年龄较大的成年人.伤害是一种伤害.

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