在不同的生物活性溶剂中探索药物的分子相互作用:对安全和高效的药物输送系统进行全面审查
Parveen Kumar1, Palak Ahir1, Sunaina Sharma1
1Department of Chemistry, Himachal Pradesh University, Shimla, 171005, Himachal Pradesh, India.
International journal of biological macromolecules
|January 12, 2026
概括
药物溶剂相互作用对于制药配方至关重要,影响药物的稳定性,溶解性和生物可用性. 了解这些分子相互作用可以提高治疗效果,并指导个性化药物开发.
科学领域:
- 药理学 药理学是指药理学的学科.
- 物理化学 物理化学
- 药物运输 药物运输 药物运输
背景情况:
- 药物溶剂相互作用对于优化制药配方至关重要,影响药物的稳定性,反应性和可溶性.
- 了解这些相互作用可以增强对药物吸收,分布,新陈代谢,运输和生物可用性的知识.
- COVID-19大流行突显了药物溶解环境对临床疗效的重要性,如抗病毒药物和重用药物所见.
研究的目的:
- 系统地审查药物和生物活性溶剂之间的分子相互作用.
- 用物理化学,光谱学和计算方法批判性地检查药物溶剂相互作用.
- 为改善药物输送提供在生理条件下的药物行为提供分子层面的洞察力.
主要方法:
- 根据PRISMA模型 (2000-2025) 进行系统审查.
- 分析物理化学 (自由能量变化),光谱 (结合常数) 和计算 (结合亲和力) 度量.
- 分子动力学,人工智能/机器学习和实验验证的整合.
主要成果:
- 药物溶剂相互作用显著影响药物的稳定性,溶解性和生物可用性,正如甲福明和拉酸等例子所示.
- 在COVID-19大流行期间,物理化学和计算数据对于批准法维皮拉维尔和氧化等药物至关重要.
- 该研究为药物溶剂相互作用提供了定量指标,为溶解行为提供了新的见解.
结论:
- 研究分子药物溶剂相互作用在药理上是重要的,影响配方,稳定性和生物可用性.
- 结合实验和计算方法的综合方法为精确的药物输送和个性化药物提供了有前景的战略.
- 这一综述作为未来研究药物溶剂相互作用的基础,改善药物安全性,疗效和药物输送性能.
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