防御性应对中的mPFC-PAG电路:在转变战略中的相关作用而不是因果作用
Meijuan Li1, Qian Wang1, Xiaoxue Li1
1The School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.
Behavioural brain research
|January 12, 2026
概括
阴下皮层 (IL) 中的神经活动与积极的回避相关,但激活中间前额叶皮层 (mPFC) 或周水管灰色 (PAG) 不能改变既定的防御行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 精神病学是一个精神病学.
背景情况:
- 防御性行为对生存至关重要,它们的失调与精神疾病有关.
- 中间前额叶皮质 (mPFC) 和周水管灰色 (PAG) 途径调节防御行为,但它们在战略选择中的作用尚不清楚.
研究的目的:
- 调查mPFC和PAG在选择主动回避 (AA) 和反应性逃脱 (RE) 策略之间的作用.
- 检查神经元激活模式和防御行为中这些大脑区域的因果控制.
主要方法:
- 在雄性大鼠中使用双向主动回避 (TWAA) 任务.
- 采用了解剖学追踪,c-Fos免疫组织化学和光遗传学.
- 结合逆行追踪与c-Fos标记来评估PAG投射神经元激活.
主要成果:
- 在喜欢AA而不是RE的老鼠中,内膜皮层 (IL) 显示出更高的神经元激活.
- 在AA和RE组之间,mPFC亚区域的PAG投射神经元的激活没有差异.
- 对IL或PAG的光遗传激活没有改变已建立的AA/RE应对偏好或运动.
结论:
- IL活动与AA行为相关,但不足以因果控制它.
- 全球mPFC或PAG的急性激活不能取代合并的防御应对策略.
- 适应性策略切换可能需要在学习过程中精确的,细胞类型特定的调制,而不是在巩固后的广泛激活.
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