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Updated: Jan 14, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
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破坏HOPS损害了APP的贩运和加工,促进了APP-CTFs的外体分泌

Derk Draper1, Anna E George2, Tineke Veenendaal3

  • 1Section Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands; Cell Biology, Neurobiology and Biophysics. Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

Neurobiology of disease
|January 12, 2026
PubMed
概括

破坏HOPS复合体会损害粉样蛋白前体蛋白 (APP) 的循环,导致神经元中有毒碎片的积累. 这种功能障碍可能会促进阿尔茨海默氏症.

关键词:
在APP-CTF中使用.阿尔茨海默病 (AD) 是一种疾病.粉样蛋白前体蛋白 (APP) 是一种前体蛋白.外基因组是外基因组的组成部分.,复杂的复杂的复杂.复原蛋白是复原体中的一个.

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