在老年移植接受者中,老年,老年和非常老的已故捐赠者的可比结果
Silke E de Boer1, Erzsi Tegzess1, Daan Kremer1
1Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.
概括
老年移植候选人可以从使用老年捐赠者 (≥65岁) 的中获益. 移植结果在各个捐赠者年龄组中都相似,这表明可以利用更多的捐赠来降低等候名单死亡率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 老年病的医生 老年病的医生
背景情况:
- 老年人 (≥65岁) 占移植等候名单的很大一部分,面临高死亡率.
- 早期的移植,即使是使用较老的捐赠器官,也可以防止等候名单死亡率.
- 关于使用较老的已故捐赠者脏的结果的数据有限.
研究的目的:
- 为了评估接受者≥65岁的移植结果,使用已故捐赠者≥65岁.
- 为了比较老年捐赠者的不同年龄类别的移植和患者存活率.
- 评估利用更多老年捐赠脏的潜力.
主要方法:
- 荷兰 (2005-2022) 的回顾性队列研究.
- 来自65岁及以上的已故捐赠者的移植对65岁及以上的接受者进行分析.
- 捐赠者分为老年人 (65-69岁),老年人 (70-74岁) 和非常老年人 (≥75岁);包括衰退的分析.
主要成果:
- 一年患者存活率:90.6%,死亡审查的移植存活率:90.2%.
- 五年患者存活率:60.1%,死亡审查的移植存活率:86.0%.
- 捐赠者年龄组 (老年,老年,非常老年) 的生存结果没有显著差异;Cox回归证实捐赠者年龄和生存之间没有关联.
结论:
- 来自老年捐赠者 (≥65岁) 的移植显示,患者和移植的存活率与年龄较大的接受者中的年轻捐赠者相比相当.
- 探索性分析表明,从非常老的捐赠者 (≥75岁) 获得器官的利用可能会增加.
- 更广泛地接受老年捐赠脏可以减少等待时间,并减少老年脏移植候选人的死亡率.
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