代谢功能障碍相关的脂肪肝炎中的氧化应激:机制和新兴的治疗策略
Yidan Chen1, Hui Yu1, Xinyu Kai1
1School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Biochemical pharmacology
|January 12, 2026
概括
氧化应激通过与炎症和细胞死亡途径相互作用,驱动代谢功能障碍相关的脂肪肝炎 (MASH) 的进展. 本综述探讨了MASH机制和针对氧化应激的研究疗法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 氧化压力研究研究 氧化压力研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和其渐进的形式,代谢功能障碍相关的脂肪性肝炎 (MASH),构成了全球重大的健康挑战.
- MASH可以发展为严重的肝脏疾病,如肝硬化和肝细胞癌,需要有效的治疗.
- 氧化应激越来越被认为是MASH病变的一个关键因素,介导炎症和肝细胞损伤.
研究的目的:
- 提供一个全面的概述氧化应激驱动MASH进展的机制.
- 在MASH中阐明氧化应激,炎症和各种形式的细胞死亡 (细胞亡,亡,铁亡) 之间的复杂相互作用.
- 总结当前和新兴的治疗策略,针对MASH治疗的氧化应激途径.
主要方法:
- 对有关MASH病原和氧化应激的现有文献进行系统审查.
- 对将氧化应激与肝脏炎症和细胞死亡联系起来的分子机制的分析.
- 对MASH中针对氧化应激的试验药物的临床前和临床数据的调查.
主要成果:
- 氧化应激成为MASH中一个中心调解者,促进肝损伤和炎症的循环.
- 氧化应激与包括亡,亡,铁亡和线粒体相关膜在内的途径之间的相互作用对MASH进展至关重要.
- 一系列治疗标和候选药物,包括合成化合物,天然产品和生物制品,正在研究以对抗MASH中的氧化应激.
结论:
- 了解氧化应激的多方面的作用对于开发有效的MASH疗法至关重要.
- 针对氧化应激途径为针对MASH的新型药理干预提供了有希望的途径.
- 对这些机制和候选药物的进一步研究可能会改善MASH患者的临床结果.
更多相关视频
09:33Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
7.8K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
1.6K
相关概念视频
Phase I Oxidative Reactions: Overview
703
Phase I biotransformation, or functionalization, is a crucial chemical process that converts drugs and other xenobiotics into more water-soluble forms, facilitating expulsion from the body. It involves oxidative, reductive, and hydrolytic reactions that add or unveil polar functional groups on lipophilic substrates. Key players in phase I reactions are the mixed-function oxidases. Situated in liver cell microsomes, these enzymes predominantly carry out drug metabolism. They require molecular...
703
Peroxisomes
19.9K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
19.9K
Electron Transport Chain: Complex I and II
18.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.4K
Radical Autoxidation
3.1K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.1K
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
682
Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
682
