免疫调节药物:流行性耳炎的掩饰罪祸首
David S Buchinsky1, Hari M Polenakovik2,3, Jonathan I Hakim1,3
1Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.
BMJ case reports
|January 12, 2026
概括
免疫检查点抑制剂 (ICI) 可能会导致罕见的副作用,如流行性耳炎 (EO). 这一案例突出显示了布罗利祖马布治疗与细胞癌患者的EO之间的潜在联系.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了各种恶性瘤的癌症治疗.
- 了解ICI副作用的全部范围对于患者管理至关重要.
- 转移性细胞癌是一种重要的瘤诊断.
研究的目的:
- 在接受 pembrolizumab 维护治疗的患者中报告一种罕见的双边膜炎 (EO) 病例.
- 为与ICI相关的尿生殖系统副作用的有限文献做出贡献.
- 提高临床医生对免疫增强药物的潜在不良事件的认识.
主要方法:
- 一个50多岁的男性患者的病例介绍,患有转移性细胞癌.
- 对病史和治疗过程的审查,包括佩布罗利祖马布的维护.
- 诊断评估导致双边膜炎 (EO) 的诊断.
主要成果:
- 该患者在接受pembrolizumab后被诊断出患有双侧膜炎 (EO).
- 这代表了第四个确定的病例,将免疫检查点抑制剂与EO联系起来.
- 这种联系虽然很少见,但表明ICI治疗的潜在不良影响.
结论:
- 双边膜炎 (EO) 是免疫检查点抑制剂 (ICI) 的罕见但可能的副作用.
- 临床医生应考虑在ICI治疗期间或之后出现相关症状的患者进行EO.
- 这一案例强调了对与新型癌症疗法相关的不常见不良事件的警的重要性.
相关概念视频
Myocarditis III: Medical Management
168
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
168
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
480
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
480
Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
Sexually Transmitted Infections
909
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
909
Pericarditis III: Medical Management
302
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
302
Myocarditis I: Introduction
367
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
367

