用于食品添加剂分析和天然药物分离的酸盐衍生品修饰的混合模式静止阶段
Liwei Chen1, Wei Wei1, Lei Zeng1
1Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Engineering Research Center of Low-carbon and High-quality Utilization of Forest Biomass, University of Guangxi, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, 530006, China.
这项研究引入了一种新的,环保的染色学静止阶段,该静止阶段来自合金. 这种材料,Si-MPAGN,表现出优异的选择性和稳定性,用于分离各种化合物,包括食品添加剂和天然药物.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 绿色化学 绿色化学
背景情况:
- 红为染色学材料提供了一个可持续的,生物相容的来源.
- 开发新的静止相对于提高分离选择性和效率至关重要.
研究的目的:
- 为了合成和表征一种混合模式静止相 (Si-MPAGN),使用烯酸衍生物.
- 评估Si-MPAGN对各种分析物的分离性能.
- 为了将Si-MPAGN与商业色谱列进行比较.
主要方法:
- 在石英上将马列奥皮马里克酸甘甲烯酸乙3-二甲基亚胺胺胺胺基 (MPAGN) 移植.
- 使用表征技术来确认成功的移植.
- 测试基,核酸,PAH,,食品添加剂和天然药物的分离能力.
- 执行量子化学计算 (ESP,IGMH) 以阐明分离机制.
主要成果:
- Si-MPAGN表现出逆相,水友相互作用和离子交换混合模式特性.
- 静止阶段通过多种相互作用 (疏水性,π-π,H-结合,离子交换) 证明了对各种分析物的高选择性.
- 在RSD<0.42%的情况下证实了出色的稳定性,优于商业C18,氨基和SAX柱.
- 通过量子化学计算阐明了分离机制,表明食品添加剂的静电相互作用占主导地位,天然药物的H键/范德瓦尔斯.
结论:
- 开发的Si-MPAGN静止相为分析分离提供了一个有前途的,多功能材料.
- 脂基材料在染色学中提供了一个可持续的替代方案.
- 混合模式特性使其在各种化合物类别中具有广泛的适用性.
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