固体器官移植中传染病的血清免疫状态的变化:20年韩国单中心研究
Jinyoung Yang1, Jae-Hoon Ko1, Sanghoon Lee2
1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Annals of laboratory medicine
|January 12, 2026
概括
韩国实体器官移植 (SOT) 接受者的最新血清免疫学数据显示,免疫特征发生了显著的代际变化. 这些发现强调了对移植候选人进行量身定制的查和及时免疫战略的必要性.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 移植医学 移植医学
背景情况:
- 越来越多的固体器官移植 (SOT) 需要更新的血清免疫学数据,因为免疫特征在几代人之间不断变化.
- 免疫状况会影响SOT接受者的预防策略的有效性.
- 评估韩国SOT接受者的当前血清免疫状态至关重要.
研究的目的:
- 评估韩国固体器官移植 (SOT) 接受者的血清免疫状态.
- 在SOT候选人中确定感染性疾病的血清阳性时间趋势和代际转变.
- 为SOT的预防策略和管理协议提供信息.
主要方法:
- 对12种传染病的移植前血清免疫学测试结果的回顾性分析.
- 包括20年来在一个中心的SOT接受者和捐赠者的数据.
- 基于测试年,年龄和出生队列的血清阳性时间趋势的评估.
主要成果:
- 对疹病毒,简单疹病毒 (HSV) 和细胞巨血病毒 (CMV) 的血清阳性在较年轻的出生队伍 (1980年代后出生) 中下降.
- 在20世纪80年代之后出生的人群中,甲型肝炎病毒和麻疹的血清阳性明显下降.
- 在Toxoplasma抗体和结核病特异性干扰素玛释放试验 (TB IGRA) 的阳性方面观察到与年龄相关的下降.
结论:
- SOT候选人的血清免疫学格局发生了变化,反映了韩国社会世代的变化.
- 有针对性的查和量身定制的管理是必不可少的,特别是在高风险的捐赠者-阳性/接受者-阴性移植时.
- 鉴于观察到免疫特征的变化,对移植候选人的及时免疫非常重要.
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