Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

575
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
575
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

6.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
6.4K
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

581
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
581
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

3.8K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
3.8K
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

521
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
521

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

NEK2A regulates PLIN2 expression through a SERBP1 dependent pathway.

iScience·2026
Same author

A Fluorescence-Based Method To Visualize Lipid Droplet And Organelle Dynamics During Mitosis in Hepatoma Cells.

Journal of visualized experiments : JoVE·2026
Same author

The role of NLRP3 inflammasome in opioid-induced neurochemical markers, therapeutic effects, and adverse effects in male mice.

Brain, behavior, and immunity·2026
Same author

Inhibitory Effects of Lansoprazole and Omeprazole on the CYP2C19-Mediated Metabolism of Arachidonic Acid to Epoxyeicosatrienoic Acids: Implications for Cardiovascular Risk.

Biological & pharmaceutical bulletin·2026
Same author

Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

SMTP-44D Exerts Renoprotective Effects against Diabetic Nephropathy via Its Anti-inflammatory and Antioxidant Action.

Biological & pharmaceutical bulletin·2026

相关实验视频

Updated: Jan 14, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K

SMTP-44D 改善高葡萄糖诱导的血管内皮功能障碍

Shiori Jono1,2, Ryosuke Shinouchi1,2, Takashi Obama3

  • 1Department of Pharmacology, Showa Medical University Graduate School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

Biological & pharmaceutical bulletin
|January 12, 2026
PubMed
概括

斯塔基博特里斯微三烯-44D (SMTP-44D) 保护糖尿病血管内皮功能障碍. 这种由真菌衍生的化合物提高了细胞活力和氧化水平,为糖尿病并发症提供了潜在的新疗法.

关键词:
葡萄藻微三烯基enol-44D 的微.糖尿病内皮功能障碍 糖尿病内皮功能障碍人类脉内皮细胞内皮细胞过高血糖症是什么意思氧化氧化是什么?可溶性环氧化酸盐酸酶的使用

更多相关视频

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

12.9K
Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
08:03

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

Published on: June 25, 2017

20.7K

相关实验视频

Last Updated: Jan 14, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K
High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
12:32

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

12.9K
Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
08:03

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes

Published on: June 25, 2017

20.7K

科学领域:

  • 生物化学 生物化学
  • 药理学 药理学是指药理学的学科.
  • 内分泌学 在内分泌学.

背景情况:

  • 慢性糖尿病并发症通常与血管疾病有关.
  • 目前糖尿病血管并发症的治疗方法有限.
  • 溶性环氧化酶 (sEH) 在血管恒温中发挥作用.

研究的目的:

  • 为了研究Stachybotrys microspora triprenyl phenol-44D (SMTP-44D) 对高葡萄糖诱导的内皮功能障碍的治疗潜力.
  • 阐明SMTP-44D对人类静脉内皮细胞 (HUVEC) 的影响背后的机制.

主要方法:

  • 培养了HUVEC并用高葡萄糖 (30毫米) 和SMTP-44D处理.
  • 评估了细胞活力,氧化 (NO) 水平,细胞内活性氧物种 (ROS) 和Akt激活.
  • 该研究使用高葡萄糖治疗模型对HUVECs进行了研究.

主要成果:

  • 高葡萄糖显著降低了HUVEC活力和氧化水平,同时增加了ROS和降低了Akt激活.
  • 在高葡萄糖条件下,SMTP-44D治疗恢复了HUVEC活力至111%,氧化水平至82%.
  • SMTP-44D有效抵消高葡萄糖诱导的氧化应激,并调节酸酸3-激酶 (PI3K) /Akt信号通路.

结论:

  • SMTP-44D显示出对糖尿病血管内皮功能障碍的显著保护作用.
  • 该化合物通过减轻氧化应激和影响PI3K/Akt通路而起作用.
  • 作为糖尿病并发症的新型治疗和预防剂,SMTP-44D显示出前景.